Pyrogen test
Mylc, which shows similar response to in vivo cells, is superior in sensitivity in sensitization and stability compared with model cells (Mono-Mac-6, etc.) used in alternative methods to animal testing.
Comparison study with the Mono-Mac-6.
Comparison study in IL-6 production assay, in which a pyrogen (LPS) was added. (expressed in OD) In Mylc-2 (blue circle), the production was detectable at lower concentrations than in Mono-Mac-6 (orange circle), indicating a higher response.
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